Type 2 Diabetes Mellitus, Hippocampus And Memory

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Asem Veeves Singh , Anand Vijayakumar Palur Ramakrishnan , Salam Ranabir , Tashi Chhojom Khom , Sarath Chandran K R , Japheth Thono , Lalrinchhani


There is strong evidence of type 2 diabetes mellitus-associated hippocampal atrophy. Insulin resistance, poor HbA1c level control, oxidative stress, vascular complication, higher cortisol levels and neuroinflammation in diabetes mellitus contribute to the reduction of hippocampus volume. The hippocampus plays an important role in the storage and retrieval of declarative memory. The hippocampus volume reduction could trigger declarative memory impairment. The present review article aims to provide an overview of the impact of type 2 diabetes mellitus on the hippocampus and its effect on memory.

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