Review Article: Recent Advancement In Transdermal Drug Delivery System (Tdds)

Abstract

TDDS is the best and easily self-administered system. It interacts with the skin and delivers the medicament in a controlled manner into the systemic circulation. It reduces/avoids the side effect related to oral therapy, like- hepatic first-pass metabolism, GIT irritation, etc. The skin infusion enhancer technique has been advanced to improve the bioavailability of the drugs. So various Transdermal dosage forms have been prepared like: Transdermal patches, Gel, Cream, Ointments, etc. The Transdermal route is a viable option to enhance the variety of drugs. Transdermal drug delivery has become the primary route of delivery for a variety of medications that would otherwise be difficult to supply. There are some advantages to Transdermal medicine administration. Primarily to prevent first-pass metabolism and a stomach environment that would render the drug inactive in pharmaceuticals used to treat skin problems as well as for systemic effects to treat ailments of other organs. The therapy of hormone replacement, pain management, smoking cessation, neurological illnesses and angina pectoris like as Parkinson's ailment are all examples of Transdermal products and applications. Formulated to distribute the medicine into the systemic circulation at an optimal pace, it must stick to the skin for the desired period and not cause sensitization or skin irritation. By-passing first-pass metabolism to enhance bioavailability Keeping pharmacokinetic peaks and troughs to a minimum, Tolerance and dosage are being improved. In Continuous Delivery, increasing patient compliance is important.