Study The Effect Of Intermittent Fasting Diet On Obese And Lipid Profile

Abstract

Obesity is a worldwide epidemic due to the availability of unhealthy food options and limited physical exercise. Restriction of the daily food intake results in weight loss, which is associated with better health outcomes including triglycerides, total cholesterol, low density lipoprotein cholesterol, blood pressure, glucose, insulin, and C-reactive protein. Intermittent fasting is a method of weight loss, as an alternative to daily caloric restriction which may improve serum high density lipoprotein and other lipids thereby reducing the risk of cardiovascular diseases, it include several forms such as alternate-day fasting or time-restricted feeding regimens, several studies published confirm that intermittent fasting can be a useful and safe therapeutical option for obesity,  it aim to weight loss  (>70%) energy restriction interspersed with normal eating, the focus of this article is obesity, lipid profile and the potential benefits of intermittent fasting on overall human health. The present study aimed to evaluate the effect of intermittent fasting for 16 hours on lipid profile and HDL-cholesterol in a sample of women in Najran. In all, thirty women overweight and obese participants (30-45) years. A 6-months quasi-experimental clinical trial was conducted on participants with low HDL <50 mg/dl. The participants were recommended to fast for 16 h during day time, five days per week for 6 months. Body weight, waist circumference, serum lipid profile, blood pressure, and blood glucose levels were measured at baseline after 6 months. The study found statistically significant difference in the weight loss between groups pre and post treatment with intermittent fasting, body measurements, including BW, BMI and WC, showed significant interaction effects (p<0.05%), indicating that there were larger reductions post the treatment with intermittent fasting (68±1, 25.1 ± 1.1 and 48 ± 2.1), compared to the results before treatment (95 ± 1, 37. 58 ± 1 and 85 ± 1.2), also significant interaction effects were observed in TC, TG, LDL, HDL, BP and blood glucose  (198 ± 1.2, 201 ± 1, 45.51 ± 0.6, 55 ± 5.0, 123 ± 1/86 ± 1.1 and 126 ± 0.2/79 ± 0.1) compared to the results before treatment (237.9 ± 1.2, 230.4 ± 3.0, 80.78 ± 26.2, 45.6 ± 11.5, 159 ± 2/110 ± 3 and 170.5 ± 1.8/95 ± 2.0) during the six months respectively. This study suggests that intermittent fasting protect cardiovascular health by improving the lipid profile and raising high density lipoprotein. Intermittent fasting may be adopted as a healthy lifestyle for the prevention, management and treatment of cardiovascular.