An Overview of Sickle Cell Disease Vaso Occlusive Crisis and Approaches to Management

Abstract

Early diagnosis, treatment, and prevention of a vaso-occlusive crisis (VOC) are critical to the management of patients with sickle cell disease. Literature search conducted through electronic databases, such as PUBMED, EMBASE. We aimed to discuss the proper management of VOC, after emphasizing the mechanism and complications of VOC in SCD. Vaso- occlusive crisis in people with SCD is a multifactorial process identified by inflammation, attachment, and multicellular aggregation of sickled RBCs, endothelial cells, platelets, and also other blood cells, resulting in vaso-occlusion and acute extreme pain.