Establishing Pharmacokinetic and Pharmacodynamic Models for Antibiotics Used in Special Paediatric Populations

Abstract

It is crucial to determine the proper dosage for the drugs prescribed for neonates. Extrapolating dosages from adults and older children is not a good idea to neonates because of the significant physiological differences that impact the distribution, metabolism, excretion, and absorption of medications. It is now feasible to gather more exact data on the pharmacokinetic characteristics of the research population as well as on an individual, as well as on intra- and interindividual variability, thanks to the widespread application of population pharmacokinetic analysis techniques in neonates. A feature of neonatal pharmacology is the heterogeneity of clinical reactions to single doses of a medication; this phenomenon is associated with interindividual variability in pharmacokinetic and pharmacodynamic outcomes, leading to a limited degree of predictability. In order to determine optimal dosages for antibiotics used in specific paediatric populations, this research will examine the fundamentals of pharmacokinetic (PK) and pharmacodynamic (PD) models.