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Many economists generally agree that openness accelerates economic growth. This paper provides a comprehensive review of the empirical research that has previously been conducted on the case of how openness to trade affects economic growth. The ongoing inconsistent results, mostly on the empirical side, which have produced confusion among researchers and policy makers over the trade-growth relationship have served as the basis for the current study. Specifically, this paper concludes that the available literature provides an affirmative answer to the question of whether or not trade openness causes economic growth. However, various issues still exist in the current literature, which needs an appropriate approach to handle them, in order to establish an explicit relationship between trade openness and economic growth.