Origanum Majorana (O. M.) Ameliorate CiprofloxacinInduced Hepatotoxicity In Rats Via Antioxidant Defense Mechanism

Abstract

Background. The etiology of ciprofloxacin-induced hepatopathy is complicated by oxidative stress. The study intends and seeing if Origanum majorana (O.M.) could protect animals with antioxidant properties. Methods. G1 (control), G2 (ciprofloxacin group), G3 and G4 (two O.M. groups rats treated with O.M. 30 mg and 45 mg), and G5 and G6 (two O. M. groups rats treated with O. M. 30 mg and 45 mg) (two combinations at 30 mg and 45 mg; with ciprofloxacin 100 mg/kg). Liver function and anti-oxidant enzymes were among the tests performed. When ciprofloxacin produced hepatotoxicity, blood levels of anti-oxidant enzymes were lower in the ciprofloxacin group, whereas O.M. boosted these enzymes in rats. Conclusions. In vivo, O.M. reduces experimental hepatotoxicity. The antioxidant defense mechanism is hypothesized to be activated as a result of this impact.