Effects Of Sodium Benzoate On Neuronal Response Of Pyramidal Neuron Of The CA1 Hippocampus In Rat Model Of Parkinson's Disease

Abstract

Introduction: Thinking and memory problems are among the most worrying potential symptoms of Parkinson's disease (PD). Sodium benzoate (NAB) is one of the compounds that is widely used in food and pharmaceutical industries and has been shown to have beneficial effects on the central nervous system, especially in the treatment of Alzheimer's and Parkinson's disease. The current study aimed at evaluating the effect of NAB on pyramidal neuron response in CA1 region of a rat model of PD.

Methods: In this experimental study, adult male Wistar rats were randomly divided into five groups:  Substantia nigra pars compacta (SNc) lesion (the lesions were induced by IP injection of Rotenone 2mg/kg/19day/48h) and four groups of NAB (lesions plus 50, 100, 150 and 200 mg/kg ip of NAB). Spontaneous neural activity was recorded for all groups in the CA1 region of the hippocampus.

Results: The obtained results showed that IntraPeritoneal (IP) injection of NAB (100 mg/kg) increased neuronal spontaneous activity in the rat model of PD.

Conclusion: The current study results suggested that acute IP injection of NAB increased neuronal response in CA1 region of hippocampal in a rat model of PD.