Effect of periodontal treatment on biomarker levels: An Update

Abstract

The risk of unfavorable systemic outcomes is thought to be increased by periodontal infections. The characteristic feature of the periodontal disease is the immune-inflammatory process that increases level of several proinflammatory cytokines such as IL-1, IL-6, TNF- α, PGE-2, and IL-8. The main role of these cytokines are to initiate inflammatory response in alone or in coordination with other metabolic factors. Standard nonsurgical therapy such as scaling and root planing (SRP) are reported to be gold standard for the periodontitis patients. In the past studies have evaluated the association of the biomarkers with the non-surgical periodontal treatment. However, there is no such comprehensive review is available that have discussed this association in details. Hence, this review is undertaken to discuss the past studies conducted in this field. The available evidence suggests that routine nonsurgical periodontal therapy, which primarily consists of scaling and root planning of the dentition, may help patients to reduce their CRP and other serum inflammatory markers between periodontal maintenance visits.