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The aim of this study was to investigate the effect of higher education on students ’acquisition of global 21st-century skills at Aqaba University College which is affiliated with AlBalqa Applied University. The researchers used the descriptive analytical approach, and a survey was conducted to achieve the purposes of the study. The study sample consisted of a number of graduates students was 56 in the academic year 2019/2020. It was concluded that there is a positive effect of university education on providing graduate students with learning, innovation, technology, life, and job skills.