Role of MDA, GGT, TAC in the diagnosis of Patients with Acute Coronary Syndrome

Abstract

Background: Oxidative stress and free radicals have an important role in developing atherosclerosis which is a cause of acute coronary syndrome. This study was measured serum MDA, GGT and TAC to compare their levels in patients with ACS.

Materials and Methods: To evaluate the levels of MDA, GGT, and TAC   we measured patients who admitted to the coronary care unit (CCU).  50   patients with ST-elevation myocardial infarction (STEMI), 50 patients with Non-ST elevation myocardial infarction (NSTEMI), 50 patients with unstable angina (UA) and 50 persons as control healthy group.MDA was determined by spectrophotometer, GGT was measured by the kinetic method and TAC was measured by sandwich ELISA method to quantify their levels.

Results: The current study has shown a significant increase in the serum level of MDA in patients with ACS apart from those with unstable angina when compared to the control group. This increase was so comparable to GGT show a higher significantly increase in NSTEMI compared to STEMI and UA. Among these groups, there was a significant difference when compared to the control group. While TAC hasn’t shown significant differences in STEMI, NSTEMI, and UA when compared to the control group.  

Conclusion: Both GGT and MDA are significantly increased in all types of ACS in an ascending manner from UA to STEMI while TAC is not influenced by stress related to ACS.