Main Article Content
The concentration of trace elements in the human body is regulated very finely. This control is carried out by certain proteins, hormones, and precipitating systems (bone tissue, hair, cornea, etc.). On the other hand, the relationship between metal ions and their binding substances is so close that changes in the state of the body can be the result of both increased and decreased content of metal ions compared to the norm. The study of tissues and body fluids for the content of elements is therefore a very important diagnostic test. A human body with a weight of 70kg contains 1050g of Ca, 245g of K, 105g of Na, 35g of Mg, 700g of P, 100g of Cl, 3g of Fe, 20mg of Mn. Some of the elements such as Cs, Rb, Sr, Ni are relatively non-toxic. Others are highly toxic - Sb, As, Ba, Rb, Hg, Ag, etc. The toxicity is strongly influenced by the form in which the metal ion is located. The formation of fat-soluble complexes with organic ligands increases toxicity. A classic example is Minimat's disease, the cause is the transformation of inorganic mercury from wastewater into methylmercury under the action of vitamin B12 contained in microorganisms, which then enter the body with water or food.