FORMULATION AND CHARACTERIZATION OF POLYMERIC NANOPARTICLES FOR ENHANCING BIOAVAILABILITY OF HERBAL ANTICANCER CASTALIN

Abstract

The destiny look at entails delivering drug/bioactive based totally on a unmarried  nanoplatform poly lactic-co- glycolic acid (PLGA) for superior efficacy, synergistic effect, and reduced toxicity. Diverse NP formulations were allotted in drug development in an try to growth performance, protection and tolerability of integrated tablets. In this context, NP formulations that increase solubility, control release, and/or affect the in vivo disposition of drugs, had been evolved to enhance the pharmacokinetic and pharmacodynamic homes of encapsulated drugs. The nanoparticles have been formulated further to then characterized for percent yield, encapsulation performance, surface morphology, particle dimension, drug distribution studies, drug polymer interaction research and in vitro drug launch profiles. The goal of this effort is to put together and compare Poly (D, L-Lactide-co-glycolide) (PLGA) Nanoparticles (NPs) of Castalin, an anticancer agent loaded by solvent displacement method by stabilizer (poly vinyl alcohol). The set NPs were characterized by FT-IR, DSC, drug loading, entrapment efficiency, particle size, and surface morphology by Atomic force microscopy (AFM), X-ray diffraction and in-vitro studies. FT-IR and DSC research indicated that there was no interplay between the drug and polymer. The morphological studies executed by using AFM showed uniform and spherical fashioned discrete particles without aggregation and easy in surface morphology with a nano length varies of 144 nm. The enormous quantity of news on PLGA NPs used as drug delivery systems during cancer management effects to see the potential of PLGA NPs used as drug delivery systems in the course of most cancer therapeutics and encourages similarly translational research.