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BACKGROUND: The phrase “non-alcoholic fatty liver disease “is used to describe fatty liver conditions that affect persons who do not consume alcohol. NAFLD is a form of fatty liver disease that is characterized by hepatic inflammation and concomitant liver fat buildup. A common kidney illness known as renal stone disease is characterized by crystal deposition in the renal medulla and urinary system. NAFLD may increase risk of nephrolithiasis. We examined the association of NAFLD with development of renal calculi in Pakistani men and women of all ages. OBJECTIVE: To find the association of renal calculi with non-alcoholic fatty liver disease detected in computed tomography. METHODOLOGY: It was a cross sectional analytical study conducted in Radiology Department, Lahore General Hospital. A total 298 patients who underwent abdomen- pelvic CT were included. Patients of both genders and with NAFLD were included. Patients with viral liver disease and liver cirrhosis, splenectomy, liver metastasis, chronic renal failure, transplanted kidney. The statistical significance of association between NAFLD and renal stone disease was assessed using chi-square test. RESULTS: In comparison to women, men had a stronger association between fatty liver and stones. NAFLD and nephrolithiasis were more prevalent in cases of age more than 40 and less prevalent in cases of age less than 20 (p for intercept
< 0.001). Renal calculi and NAFLD ration were significantly correlated with hypertension (p = 0.06). Diabetes Mellitus had a non-significant relationship (p = 0.024). Mean of renal calculi sizes
4.35 and standard deviation was 4.30. CONCLUSION: Study indicates that prevalence of nephrolithiasis was significantly higher in the NAFLD as compare to healthy groups. Renal calculi were significantly associated with hypertension and Diabetes Mellitus in males have higher prevalence of renal calculi than females.