Kinetic Study Of Novel Metal- Nucleobase Complex For Phenol Oxidation Enzyme-Mimicking Activity
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Nucleobase Adenine analogues are employed as various therapeutic Medicinal agents. We preapared a novel copper metalated Cu (II) complex of modified Adenine by synthesizing N7 alkyl adenine and metalizing it with Cu (II) salt. This complex catalyses the oxidation of phenolic substrates like catechol, 4-hydroxy anisole, and 4-t-butyl catechol. Because the modified ligand complex is insoluble with general organic solvents, heterogeneous catalytic behaviour, it may be reusable. A Michaelis-Menten kinetic analysis was conducted to compare the catalytic oxidation of metal nucleobase complexes with substrates to that of mushroom tyrosinase. The catalytic oxidation of metal nucleobase complexes with substrates was explored. It was observed that the copper-metalated adenine complex exhibited phenol oxidation activity and enzyme mimicking activity similar to tyrosinase.