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A thousand and one factors influence firm profitability and overall performance. This study looked at how monetary policies affected the performance of Nigeria's listed deposit money banks. The study's goal is to examine monetary policy instruments such as open market operations, cash reserve requirements, liquidity ratios, and interest rates to determine their impact on banks, whether significant or not, using return on assets as a performance metric. The purposive sampling technique was used to select five quoted deposit money banks in the financial services industry. The study's data came from CBN statistical bulletins and the annual reports of the companies studied, which ranged from 2012 to 2021. Using multiple linear regression and Pearson product correlation analysis, the hypotheses were tested to see if the null hypothesis was accepted or not. According to the study's findings, open market operations have no significant positive effect on the profitability of Nigeria's listed deposit money banks. Further research revealed that cash reserve ratios have a significant positive effect on the profitability of Nigeria's listed deposit money banks. Based on the findings, the study's main conclusion is that monetary policies have a significant influence on the profitability of Nigerian listed deposit money banks when they are pooled together. Among the recommendations was to extend monetary policy beyond OMO because it had no significant influence. According to the study, banks should maintain an adequate cash reserve ratio because it has a significant impact on performance. Deposit money banks should place a greater emphasis on financial performance factors over which they have direct control, such as capital adequacy, asset quality, management efficiency, earnings ability, and liquidity management.