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Metacognitive strategies play an essential role in students’ learning and achievement; therefore, identifying their antecedents should be considered. Metacognition is a concept that has been used to refer to variety of epistemological processes. Metacognition essentially means cognition about cognition; that is, it refers to second order cognitions: thoughts about thoughts, knowledge about knowledge, or reflections about actions. So, if cognition involves perceiving, understanding, remembering and so forth, then metacognition involves thinking about one's own perceiving, understanding, remembering etc. these various cognitions about cognitions can be labeled 'meta perception', 'meta-comprehension' and 'meta memory' with 'metacognition' remaining the super ordinate term. Metacognitive knowledge refers to acquired knowledge about cognitive processes, knowledge that can be used to control cognitive processes. This study indicated how self-esteem, as motivational beliefs, affects the meta-cognitive strategies of medical students using a SEM approach. In the present study simple random sampling technique is adopted and 200 under graduate students are selected as sample. Statistical techniques adopted percentage analysis; ‘t’ test is employed. The finding of the study reveals that the under graduate students have above average level of metacognition in relation to their self-esteem.