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Early breastfeeding initiation is breastfeeding immediately after the baby is born by making skin contact within 1 hour. This study aims to analyze the determinants of maternal behaviour towards the decision to initiate early breastfeeding in the working area of Toddopuli Health Center, Makassar City. This type of research is a quantitative study with cross-sectional study design. The study population was 315 mothers giving birth in the toddopuli health centre work area in 2019. The sample of this study was 75 mothers giving birth, taken by simple random sampling. Data were analyzed using chi-square and logistic regression. The results showed that 57.3% of mothers gave birth to initiate early breastfeeding. Results of Chi-square test showed that access to information (p =0.036), family support (p = <0.001), and support from health workers (p =<0.001) were associated with the decision to initiate early breastfeeding (p<0.05). The results of the logistic regression test showed that there was a significant effect on access to information (p =0.018), family support (p =0.004) and support from health workers (p = <0.001) affected the decision to initiate early breastfeeding (p <0.05). The variable with the greatest influence on the mother's decision to initiate early breastfeeding was the support of health workers with an OR = 27.65. Health workers are advised to increase programs related to providing support and education related to early initiation of breastfeeding to pregnant women who are about to give birth.